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Metal-ligand coordination and antiradical activity of a trichromium(III) complex with the flavonoid naringenin |
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| Authors: | Anamaria D P Alexiou Carla C Decandio Sabrina da N Almeida Marcelo J P Ferreira Paulete Romoff Reginaldo C Rocha |
| Institution: | 1. Escola de Engenharia, Universidade Presbiteriana Mackenzie, S?o Paulo, Brazilanamaria.alexiou@mackenzie.br;3. Escola de Engenharia, Universidade Presbiteriana Mackenzie, S?o Paulo, Brazil;4. Departamento de Botanica, Instituto de Biociências, Universidade de S?o Paulo, S?o Paulo, Brazil;5. Los Alamos National Laboratory, Los Alamos, NM, USA |
| Abstract: | The trinuclear chromium(III) complex Cr3O(CH3CO2)6(L)(H2O)2] (where L is the monoanion of the flavonoid naringenin) was synthesized and characterized. Density functional theory (DFT) calculations and quantum theory of atoms in molecules (QTAIM) analysis show that the flavonoid binds to CrIII as an O,O-bidentate ligand via the 5-hydroxy and 4-oxo groups. Reactions with 2,2-diphenyl-1-picrylhydrazyl (DPPH) indicate that the antiradical activity of this flavonoid-metal complex is enhanced in comparison with uncoordinated naringenin. |
| Keywords: | Antiradical activity chromium(III) complexes flavonoids metal-oxo cluster naringenin |