Synthesis of aryl acetamides by aminocarbonylation of benzylic chlorides using carbamoylsilane as an amide source |
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Authors: | Wenjun Zhang Shenghua Han |
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Institution: | College of Chemistry and Materials Science, Shanxi Normal University, Linfen, Shanxi, China |
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Abstract: | Using N-methyl-N-(1-phenyl)ethylcarbamoyl(trimethyl)silane as an amide source, the direct transformation of benzylic chlorides into the corresponding aryl acetamides through palladium-catalyzed aminocarbonylation is described. The electronic property and the relative position of substituents on the aromatic ring impact the coupling efficiency. |
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Keywords: | Amides aminocarbonylation benzylic halides carbamoylsilane synthetic methods |
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