A new rearranged abietane diterpene from Clerodendrum inerme with antioxidant and cytotoxic activities |
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| Authors: | Le Ba Vinh Nguyen Thi Minh Nguyet Seo Young Yang Jang Hoon Kim Le Thi Vien Phan Thi Thanh Huong |
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| Affiliation: | 1. College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea;2. Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam;3. Korea Atomic Energy Research Institute, Jeongeup, Republic of Korea;4. Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam |
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| Abstract: | Eight compounds were isolated from the leaves of Clerodendrum inerme, including one new rearranged abietane diterpene, crolerodendrum B (1). Their structures were determined by means of spectroscopic methods including one-dimensional and two-dimensional nuclear magnetic resonance (1-D and 2-DNMR), high-resolution electrospray ionisation mass spectrometry (HR-ESI-MS) and circular dichroism (CD). The DPPH radical scavenging and cytotoxic activities of isolated compounds against MCF7 (breast), HCT116 (colon) and B16F10 (melanoma) cancer cell lines were evaluated. Compounds 1, 3 and 4 exhibited strong DPPH radical-scavenging effects (ED50 values of 17.6 ± 2.1, 10.1 ± 0.8 and 11.3 ± 0.3 μM, respectively) and 4 showed strong cytotoxicity against the HCT116 cell line (IC50 = 3.46 ± 0.01 μM). |
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| Keywords: | Clerodendrum inerme Verbenaceae abietane diterpene crolerodendrum B antioxidant cytotoxic |
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