Neolignan and phenylpropanoid compounds from the fruits of Illicium simonsii Maxim |
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| Authors: | Peng-Yu Zhuang Ming-Hua Chen Ya-Nan Wang Ya-Jing Feng Dan-yang Zhang |
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| Institution: | 1. School of Pharmacy, North China University of Science and Technology, Tangshan, People’s Republic of China;2. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and PekingUnion Medical College, Beijing, People’s Republic of China;3. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and PekingUnion Medical College, Beijing, People’s Republic of China |
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| Abstract: | One new sesqui-neolignan compound, namely, sesqui-illisimonan A (1), one new neolignan, illisimonan A (2), and one new phenylpropanoid compound, illisimoid A (3) were isolated from the fruits of Illicium simonsii Maxim. The structures and absolute configurations of these compounds were determined by extensive spectroscopic, including NMR, circular dichroism and calculated electronic circular dichroism methods. The antioxidant activities of compounds 1–3 were also evaluated. Vitamin E was selected as the positive control (IC50 = 49.73 ± 0.88 μM). Compounds 1 and 2 exhibited in vitro antioxidant activity with an IC50 value of 55.76 ± 1.30 and 59.36 ± 0.50 μM, respectively. However, the compound 3 didn’t show obvious antioxidant activity. |
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| Keywords: | Illicium simonsi Maxim sesqui-neolignan phenylpropanoid sesqui-illisimonan A |
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