Forsskamide,a new ceramide from aerial parts of Forsskaolea tenacissima Linn. |
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| Authors: | Hamdy K. Assaf Alaa M. Nafady Ahmed E. Allam Ashraf N. E. Hamed Mohamed S. Kamel Kuniyoshi Shimizu |
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| Affiliation: | 1. Faculty of Pharmacy, Department of Pharmacognosy, Al-Azhar University, Assuit, Egypthamdyss200@yahoo.com hamdyss200@azhar.edu.eg;3. Faculty of Pharmacy, Department of Pharmacognosy, Al-Azhar University, Assuit, Egypt;4. Faculty of Pharmacy, Department of Pharmacognosy, Minia University, Minia, Egypt;5. Division of Systematic Forest and Forest Products Sciences, Department of Agro-Environmental Sciences, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka, Japan |
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| Abstract: | Although the various folk medicine uses and the biological activity of Forsskaolea tenacissima L., few chemical constituents of this plant have been reported, this provoked us to make our study. Forsskamide, a new ceramide was isolated from aerial parts of F. tenacissima L. (Urticaceae). The chemical structure was established by different spectroscopic methods (1H, 13C-NMR, HMBC, HSQC, ROESY, FAB-MS and HR-FAB-MS). Forsskamide showed a moderate cytotoxic activity by (MTT) method against human colorectal carcinoma cell line (HCT-116) with IC50 33.25 μM in comparison with 5-fluorouracil IC50 26.42 μM. While, it did not show any activity against human hepatocarcinaoma cell line (HepG-2). |
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| Keywords: | Forsskaolea tenacissima Urticaceae Forsskamide ceramide and cytotoxicity |
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