Microbial carbonylation and hydroxylation of 20(R)-panaxadiol by Aspergillus niger |
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| Authors: | Bin Yan Zhihua Chen Xuguang Zhai Guibo Yin Yafei Ai |
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| Affiliation: | 1. Institute of Pharmaceutical Engineering, Jiangsu College of Engineering and Technology, Nantong, PR China;2. School of Pharmacy, Nantong University, Nantong, PR China |
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| Abstract: | 20(R)-panaxadiol (PD) was metabolised by the fungus Aspergillus niger AS 3.3926 to its C-3 carbonylated metabolite and five other hydroxylated metabolites (1–6). Their structures were elucidated as 3-oxo-20(R)-panaxadiol (1), 3-oxo-7β-hydroxyl- 20(R)-panaxadiol (2), 3-oxo-7β,23α-dihydroxyl-20(R)-panaxadiol (3), 3,12-dioxo- 7β,23β-dihydroxyl-20(R)-panaxadiol (4), 3-oxo-1α,7β-dihydroxyl-20(R)-panaxadiol (5) and 3-oxo-7β,15β-dihydroxyl-20(R)-panaxadiol (6) by spectroscopic analysis. Among them, compounds 2–6 were new compounds. Pharmacological studies revealed that compound 6 exhibited significant anti-hepatic fibrosis activity. |
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| Keywords: | Biotransformation 20(R)-panaxatriol Aspergillus niger anti-hepatic fibrosis |
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