A pair of enantiomeric 5-oxabicyclic[4.3.0]lactam derivatives and one new polyketide from the marine-derived fungus Penicillium griseofulvum |
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| Authors: | Jian-Kun Yang Bin Zhang Tong Gao Meng-Yue Yang Guo-Zheng Zhao Hua-Jie Zhu |
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| Affiliation: | 1. Key Laboratory of Medicinal Chemistry and Molecular Diagnostics of Education Ministry of China, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmaceutical Sciences, Hebei University, Baoding, People’s Republic of China;2. The Department of General Surgery, No. 2 Hospital of Baoding, Baoding, People’s Republic of China |
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| Abstract: | A pair of enantiomeric 4-oxabicyclic[4.3.0]lactam derivatives, (+)- and (?)-penicilactam A (1), and one new polyketide derivative penicitrinone F (2) were isolated from the marine-derived fungus Penicillium griseofulvum GT-10. Their structures and absolute configurations were elucidated through extensive spectroscopic analyses combined with the calculated ECD spectra. Penicitrinone F (2) had moderate inhibitory activity towards Bacillus subtilis with a MIC value of 6.3 μM. |
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| Keywords: | Penicillium griseofulvum bicyclic lactam polyketide antibacterial activity |
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