A new antifungal and antiprotozoal bibenzyl derivative from Gavilea lutea |
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| Authors: | Sylvian Cretton Alejandra Oyarzún Davide Righi Lamia Sahib Marcel Kaiser |
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| Institution: | 1. School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Geneva, Switzerland;2. Faculty of Science, University of Magallanes, Punta Arenas, Chile;3. Swiss Tropical and Public Health Institute, Basel, Switzerland;4. University of Basel, Basel, Switzerland |
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| Abstract: | A new bibenzyl derivative (4), together with two glycosylated flavonoids (1 and 2), batatasin III (3) and the phenanthrene isohircinol (5) were isolated from the aerial parts of Gavilea lutea. Their structures were elucidated on the basis of spectroscopic studies including 1D and 2D NMR, UV, IR and HRESIMS. All isolated compounds were evaluated for their antifungal activity towards Candida albicans. The new compound 4 showed inhibitory activity with a MIQ of 50 μg. In addition, compound 4 exhibited a selective activity (IC50 = 2.3 μg/mL) against Leishmania donovani. |
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| Keywords: | Gavilea lutea bibenzyls gavilein antifungal activity antiprotozoal activity |
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