New chemical constituents from the Piper betle Linn. (Piperaceae) |
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| Authors: | Akhtar Atiya Barij Nayan Sinha |
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| Institution: | 1. Division of Pharmacognosy and Phytochemistry, Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Indiaatiya3@gmail.com atiya_aredcarnation@yahoo.com;3. Division?of Medicinal Chemistry, Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, India |
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| Abstract: | The phytochemical investigation of chloroform extract from Piper betle var. haldia, Piperaceae, leaves has resulted in the isolation of two new chemical constituents which were identified as 1-n-dodecanyloxy resorcinol (H1) and desmethylenesqualenyl deoxy-cepharadione-A (H4), on the basis of spectroscopic data 1D NMR (1H and 13C) and 2D NMR (1H-1H COSY and HMBC) as well as ESI-MS, FT-IR and HR-ESI-MS analyses. Compounds H1 and H4 showed excellent antioxidant DPPH free radical scavenging activity with IC50 values of 7.14 μg/mL and 8.08 μg/mL compared to ascorbic acid as a standard antioxidant drug with IC50 value of 2.52 μg/mL, respectively. Evaluation of cytotoxic activity against human hepatoma cell line (PLC-PRF-5) showed moderate effect with the GI50 values of 35.12 μg/mL for H1, 31.01 μg/mL for H4, compared to Doxorubicin® as a standard cytotoxic drug with GI50 value of 18.80 μg/mL. |
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| Keywords: | Piperaceae Piper betle chemical constituents antioxidant cytotoxic SAR |
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