Isolation and structure determination of a new diketopiperazine dimer from marine-derived fungus Aspergillus sp. SF-5280 |
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| Authors: | Kwang-Ho Cho Jae Hak Sohn |
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| Affiliation: | 1. College of Pharmacy, Wonkwang University, Iksan, Republic of Korea;2. College of Medical and Life Sciences, Silla University, Busan, Republic of Korea |
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| Abstract: | A new diketopiperazine dimer designated as SF5280-415 (1) was isolated from an EtOAc extract of the marine-derived fungus Aspergillus sp. SF-5280 by various chromatographic methods. The structure of 1 was mainly determined by analysis of the NMR spectroscopic data and MS data, along with Marfey’s method. This compound is a new diastereoisomer of known bispyrrolidinoindoline diketopiperazine alkaloid WIN 64745, which possesses unique architecture biosynthetically derived from an indole oxidation reaction of tryptophan. |
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| Keywords: | Diketopiperazine alkaloids marine-derived fungi fungal secondary metabolites Aspergillus sp. |
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