Transition metal-free tandem pyridinyl–allyl–allyl cross-coupling reaction |
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| Authors: | Lili Zhang Hongli Li Wenguang Yin Jianfeng Xu Maozhong Miao |
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| Institution: | Department of Chemistry, Zhejiang Sci-Tech University, Hangzhou, P. R. China |
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| Abstract: | A transition metal-free, direct one-pot domino allylation reaction of 2-pyridinyl Grignard reagents with polysubstituted allyl chlorides for the regioselective synthesis of pyridinyl-substituted 1,5-diene derivatives has been disclosed. The reaction presumably proceeded through the coupling of polysubstituted allyl chloride to 2-PyMgX, which was in situ generated from 2-bromopyridine with i-PrMgCl·LiCl. |
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| Keywords: | Allylation cross-coupling metal-free pyridines tandem reaction |
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