A new diarylheptanoid from Alpinia officinarum promotes the differentiation of 3T3-L1 preadipocytes |
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| Authors: | Xuguang Zhang Xiaopo Zhang Yong Wang Feng Chen Youbin Li Yonghui Li |
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| Affiliation: | 1. School of Pharmaceutical Science, Hainan Medical University, Haikou, P.R. China;2. Hainan Provincial Key Laboratory of R&3. D of Tropical Herbs, Hainan Medical University, Haikou, P.R. China |
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| Abstract: | A new diarylheptanoid, namely trans-(4R,5S)-epoxy-1,7-diphenyl-3-heptanone (1), and a new natural product, 7-(4″-hydroxy-3″-methoxyphenyl)-1-phenyl-hepta-4E,6E-dien-3-one (2), were obtained from the aqueous extract of Alpinia officinarum Hance, together with three other diarylheptanoids, 5-hydroxy-1,7-diphenyl-3-heptanone (3), 1,7-diphenyl-4E-en-3-heptanone (4) and 5-methoxy-1,7-diphenyl-3-heptanone (5). The structures were characterised mainly by analysing their physical data including IR, NMR and HRMS. This study highlights that the 4,5-epoxy moiety in 1 is rarely seen in diarylheptanoids. In addition, the five isolates were tested for their differentiation activity of 3T3-L1 preadipocytes. The results showed that these compounds could dose-dependently promote adipocyte differentiation without cytotoxicity (IC50 > 100 μM). |
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| Keywords: | Alpinia officinarum Hance diarylheptanoid 3T3-L1 preadipocytes differentiation |
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