Waste-grass-mediated green synthesis of silver nanoparticles and evaluation of their anticancer,antifungal and antibacterial activity |
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| Authors: | Mehrdad Khatami Iraj Sharifi Marcos A. L. Nobre Niloofar Zafarnia |
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| Affiliation: | 1. Nanobioelectrochemistry Research Center, Bam University of Medical Sciences, Bam, Iran;2. Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iranmehrdad7khatami@gmail.com;4. Leishmaniasis Research Center, Kerman University of Medical Sciences, Kerman, Iran;5. Department of Physics, School of Technology and Sciences, Sao Paulo State University – UNESP Presidente Prudente Brazil, Sao Paulo, Brazil |
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| Abstract: | Grass waste was used for transform an inexpensive waste into health. Silver nanoparticles (AgNPs) have been synthesized using waste material (dried grass). The average size of silver nanoparticles observed in transmission electron images was estimated to be about 15?nm. The anticancer, antifungal and antibacterial effect of AgNPs were studied in vitro. The minimum inhibitory concentration of AgNPs against Pseudomonas aeruginosa and Acinetobacter baumannii was calculated about 3?µg/ml. The highest level of inhibitory effect of AgNPs against Fusarium solani was close to 90% at a concentration of 20?μg/ml of AgNPs. An inhibitory effect on the cancer cell growth is reach, by increasing the concentration of AgNPs to 5?µg/ml; the cancer cells’ survival decreases about 30%. Western results showed that the expression of Cyclin D1 protein of MCF-7 cell line decreased after treatment with the effective concentration of AgNPs. |
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| Keywords: | Waste material green synthesis inhibitory effect antifungal antibacterial nanoparticles |
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