General methods for flash chromatography using disposable columns |
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| Authors: | William C Stevens Jr Daniel C Hill |
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| Institution: | (1) Exelixis, Inc., San Diego, CA, USA;(2) AstraZeneca Pharmaceuticals LP, 1800 Concord Pike, Wilmington, DE 19803, USA |
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| Abstract: | As technology has evolved available guidelines for normal-phase flash chromatography have become less relevant. Years of experience
performing chromatography with disposable columns have been condensed into simple guidelines useful for translating TLC results
into either isocratic- or gradient-flash chromatography. The described studies should provide researchers with a means of
selecting adequate columns and guidelines to reduce the waste of solvents, silica, time, and money.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users.
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| Keywords: | Silica gel Flash chromatography |
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