Functionalized Gold Nanoclusters Identify Highly Reactive Oxygen Species in Living Organisms |
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| Authors: | Yangzhouyun Xie Yunlei Xianyu Nuoxin Wang Zhaoyang Yan Yong Liu Kui Zhu Nikos S Hatzakis Xingyu Jiang |
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| Institution: | 1. CAS Center for Excellence in Nanoscience, CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing, China;2. University of Chinese Academy of Sciences, Beijing, China;3. Sino‐Danish Center for Education and Research, Beijing, China;4. China Agricultural University, Beijing, China;5. Department of Chemistry, University of Copenhagen, Copenhagen, Denmark |
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| Abstract: | Surface engineering of nanomaterials allows fine tuning of their interactions with biological systems, and thus can benefit their applications in monitoring intracellular events. Herein, the facile synthesis of ligand‐functionalized gold nanoclusters (AuNCs) as intracellular probes targeting highly reactive oxygen species (hROS, such as ?OH, ClO?, and ONOO?) is demonstrated. Selected ligands such as quaternary ammonium and oligopeptides are utilized to modulate the surface chemistry of AuNCs. It is shown that AuNCs decorated with the cell‐penetrating oligoarginine peptide facilitate cellular uptake and intracellular imaging of hROS in living cells and the zebrafish, with high stability and selectivity. |
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| Keywords: | fluorescent imaging gold nanoclusters intracellular detection reactive oxygen species |
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