Multinuclear Pd/Zn complex-catalyzed asymmetric alkylative ring-opening reaction of oxabicyclic alkenes |
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Authors: | Endo Kohei Tanaka Keisuke Ogawa Mika Shibata Takanori |
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Institution: | Waseda Institute for Advanced Study, Shinjuku, Tokyo, Japan. kendo@aoni.waseda.jp |
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Abstract: | A multinuclear palladium catalyst can be used to realize the efficient catalytic asymmetric alkylative ring-opening reaction of oxabicyclic alkenes using dimethylzinc. The use of (R)-BINOL-PHOS bearing bisphosphine and diol moieties is essential for achieving excellent catalytic performance; the corresponding monophosphine and hydroxy-protected derivatives showed lower catalytic activities and/or enantioselectivities. The generation of Pd/Zn-multinuclear complexes is a key feature of the present catalysis. |
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