| DCC/DMAP mediated esterification of hydroxy and non-hydroxy olefinic fatty acids with β-sitosterol:In vitro antimicrobial activity |
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| 作者姓名： | Nida N.Farshori Mudasir R.Banday Zeeshan Zahoor Abdul Rauf |
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| 作者单位： | a Department of Chemistry, Aligarh Muslim University, Aligarh 202002, India;b Department of Biochemistry, Aligarh Muslim University, Aligarh 202002, India |
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| 基金项目： | The authors thank the Chairman, Department of Chemistry, AMU, Aligarh, for providing necessary facilities and SAIF Panjab University, Chandigarh for recording the spectra. |
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| 摘 要： | <正>A new series of fatty alkenoates were synthesized using an appropriate synthetic route involving DCC and DMAP as catalysts. Compounds were characterized by their spectral data.All the synthesized compounds were evaluated for their in vitro antimicrobial activity.The minimum inhibitory concentration(MIC),minimum bacterial concentration(MBC) and minimum fungicidal concentration(MFC) were determined for test compounds as well as for reference standards.Among the compounds tested, compounds having hydroxy group at the fatty acid chain showed the most potent antibacterial as well as antifungal activities.
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| 关 键 词： | β-Sitosterol |
| 收稿时间： | 6 November 2009 |
DCC/DMAP mediated esterification of hydroxy and non-hydroxy olefinic fatty acids with β-sitosterol: In vitro antimicrobial activity |
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| Nida N.Farshori,Mudasir R.Banday,Zeeshan Zahoor,Abdul Rauf.DCC/DMAP mediated esterification of hydroxy and non-hydroxy olefinic fatty acids with β-sitosterol: In vitro antimicrobial activity[J].Chinese Chemical Letters,2010,21(6):646-650. |
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| Authors: | Nida NFarshoria Mudasir RB aya Zeeshan Zahoorb Abdul Rauf a |
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| Institution: | a Department of Chemistry, Aligarh Muslim University, Aligarh 202002, India;b Department of Biochemistry, Aligarh Muslim University, Aligarh 202002, India |
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| Abstract: | A new series of fatty alkenoates were synthesized using an appropriate synthetic route involving DCC and DMAP as catalysts. Compounds were characterized by their spectral data. All the synthesized compounds were evaluated for their in vitro antimicrobial activity. The minimum inhibitory concentration (MIC), minimum bacterial concentration (MBC) and minimum fungicidal concentration (MFC) were determined for test compounds as well as for reference standards. Among the compounds tested, compounds having hydroxy group at the fatty acid chain showed the most potent antibacterial as well as antifungal activities. |
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| Keywords: | Fatty acids DCC DMAP IR NMR Mass Antimicrobial activity |
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