Synthesis and biological activities of novel 2-amino-1,3-thiazole-4-carboxylic acid derivatives |
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Authors: | Feng-Yun Li Xiao-Feng Guo Zhi-Jin Fan Yu-Qing Zhang Guang-Ning Zong Xiao-Lin Qian Liu-Yong Ma Lai Chen Yu-Jie Zhu Kalinina Tatiana Yury Yu Morzherin Nataliya P Belskaya |
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Institution: | 1.State Key Laboratory of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering, Nankai University, Tianjin 300071, China;2.The Ural Federal University Named after the First President of Russia B. N. Yeltsin, Ekaterinburg 620002, Russia |
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Abstract: | A series of novel 2-amino-1, 3-thiazole-4-carboxylic acid derivatives were designed and synthesized. Their structures were confirmed by melting points, IR, 1H NMR, 13C NMR, and HRMS or elemental analysis. Biological activities of all title compounds including fungicidal activity and antivirus activity were evaluated systematically. Preliminary bioassays indicated that these compounds exhibited good fungicidal activity at 50 μg/mL, compounds 4b and 4i exhibited over 50% activity against six fungi tested. Most compounds showed good activity against TMV with different models in vivo at 100 μg/mL. Compounds 4c and 4e stood out with high effects against TMV in vivo in all models tested, including protective, inactivative, curative, and inductive activities. These data demonstrate a new strategy for fungi and virus control. |
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Keywords: | 1 3-Thiazole derivatives Fungicidal activity Anti-TMV activity |
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