Amphiphilic poly(ethylene glycol)-b-poly(ethylene brassylate) copolymers: One-pot synthesis,self-assembly,and controlled drug release |
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| Authors: | Jiu-Cun Chen Jun-Zhi Li Jian-Hua Liu Li-Qun Xu |
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| Institution: | 1.Institute for Clean Energy & Advanced Materials, Southwest University, Chongqing 400715, China;2.State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071, China;3.Chongqing Key Laboratory for Advanced Materials & Technologies of Clean Energies, Chongqing 400715, China |
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| Abstract: | A set of amphiphilic poly(ethylene glycol)-b-poly(ethylene brassylate) (PEG-b-PEB) copolymers based on the PEB hydrophobic block was first synthesized by ring-opening polymerization of ethylene brassylate with an organic catalyst. The EB/PEGmolar ratios and reaction times were adjusted to achieve different chain lengths of PEB. Block copolymers that were characterized by 1H NMR and GPC could selfassemble into multimorphological aggregates in aqueous solution, which were characterized by DLS and TEM. The hydrophobic doxorubicin (DOX) was chosen as a drug model and successfully encapsulated into the nanoparticles. The release kinetics of DOX were investigated. |
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| Keywords: | Poly(ethylene brassylate) Self-assembly Nanoparticles Controlled drug release |
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