Water dispersible hydroxyapatite nanoparticles functionalized by a family of aminoalkyl phosphates |
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Authors: | Yi-Rou Jiang Fu-Hua Sun Xiao-Yong Zhou Wei-Bo Kong Xing-Yi Xie |
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Institution: | Department of Polymeric Biomaterials and Artificial Organs, College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, China |
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Abstract: | A series of aminoalkyl phosphates (AAP-n, with carbon number n ranging from 2 to 6) are used as surface modifiers to prepare hydroxyapatite hydrocolloids. The resulting nanoparticles (Cn-HA) possess a coreshell structure where an ionized layer of calcium-(AAP-n) complex +H3N-(CH2)n-OPO3Ca] encapsulates each hydroxyapatite core. Long-term colloidal stability is achieved due to the electrostatic repulsion among the suspending particles. The incorporation of AAP-n results in a preferential crystal growth along c-axis, showing an increasing aspect ratio of particles from C2-HA to C6-HA. Preliminary cell culture using osteoblast-like MG63 cells shows no cytotoxicity associated with the as-prepared Cn-HA particles. The functional amino groups around the nanoparticles could be used to graft various organic chains to prepare homogeneous HA/polymer composites as bone grafting materials. |
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Keywords: | Hydroxyapatite Hydrocolloid Aminoalkyl phosphate Cytotoxicity |
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