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Synthesis and structures of malonate derivative-calix[4]arene conjugates
Authors:Wen-Jing Hu  Ming-Liang Ma  Yahu A Liu  Jiu-Sheng Li  Biao Jiang  Ke Wen
Institution:a Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210, China; b Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University, Shanghai 200062, China; c Medicinal Chemistry, ChemBridge Research Laboratories Inc., San Diego, CA 92127, USA; d School of Physical Science and Technology, ShanghaiTech University, Shanghai 201210, China
Abstract:A series of malonate derivatives-calix4]arene conjugates were synthesized through Knoevenagel condensation reaction between formyl-tetrapropoxycalix4]arene and malonate derivatives. The structures of the resulting malonate derivative functionalized calix4]arenes were characterized by NMR spectroscopy, mass spectrometry and even single crystal X-ray diffraction analysis.
Keywords:Calix[4]arene  Malonate derivatives  Knoevenagel condensation reaction  
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