Viscosity Behavior of Some Synthetic Polypeptides at Low Concentration |
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| Authors: | M V R Rao M Atreyi Alok R Ray |
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| Institution: | 1. Department of Chemistry , University of Delhi , Delhi, 110 007, India;2. Department of Chemistry , University of Delhi , Delhi, 110 007, India;3. Biomedical Engineering Division , Indian Institute of Technology , Delhi, 110 029, India |
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| Abstract: | The viscosity of poly(γ-benzyl L-glutamate)(PBLG), poly -carbobenzoxy-L-lysine (PCBL), polyglycine (PG), and fivetricopolypeptides (glux-lysy -glyz) was studied as a function of concentration at 25°C. The solvents used include two random coil solvents, a theta solvent and a helicogenic solvent. The Huggins plots of all the systems except polyglycine showed anomalously high reduced viscosity values at low concentration of solutions. A variation of 20°C in the temperature of some of the systems did not show any marked effect on the abnormality in the Huggins plots. Various factors likely to cause abnormality were considered; disentanglement of the polypeptide chains appeared to be the prime factor responsible for the anomalous rise in the reduced viscosity. |
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