吡啶-2-羧酸钴的CO加合性能与催化羰化合成苯乙酸研究

吡啶羧酸与过渡金属离子形成的配合物是一类重要的均相氧化、羰化、聚酮反应催化剂 ,这些催化剂对ＣＯ、Ｏ2 、ＲＣＨ =ＣＨ2 、ＲＸ、ＣＨ3ＯＨ等小分子均具有良好的活化功能 ,此类小分子均能在配合物分子中进行氧化加成插入、转位及还原消除等过程合成相应的有机化合物 ,其中吡啶 - 2 -羧酸钴对氧化羰化合成碳酸酯、聚酮显示出较好的催化活性1,2 ] 。苯乙酸是医药、农药及香料合成的重要中间体 ,传统的合成路线为苯乙氰水解法。自本世纪 6 0年代以来 ,过渡金属配合物催化卤苄羰化合成苯乙酸的新方法引起了人们的极大兴趣。迄今 ,见诸文献…

CARBONYLATION OF BENZYL CHLORIDE TO PHENYLACETIC ACID CATALYZED BY COBALT PYRIDINE-2- CARBOXYLATE

Cobalt bis(2-pyridinecarbooxylate)-tetrahydrate (Co(Pyca)2·4H2O) has been prepared with the reaction of 2-pyridinecarboxylic acid and CoCO3. Elementary analysis, ICP-AES, IR were used to characterize the structure of the compound. It is found that this complex can catalyze carbonylation of benzyl chloride to phenylacetic acid under 333～358K and over 1MPa CO. The yield of phenylacetic acid is 17.5%, and the catalyst is also unsensitive to oxygen and water. The addition of base and benzyl chloride has critical effect on this reaction. One molecule of Co(Pyca)2·4H2O can combine with two CO molecules under 323K and 0.1MPa CO.