Detection of phosphorylation states by intermolecular sensitization of lanthanide-peptide conjugates |
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Authors: | Elena Pazos Marko Goličnik José L Mascareñas M Eugenio Vázquez |
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Affiliation: | Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares, Departamento de Química Orgánica and Unidad Asociada al CSIC. Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain. joseluis.mascarenas@usc.es eugenio.vazquez@usc.es. |
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Abstract: | The luminescence of a designed peptide equipped with a coordinatively-unsaturated lanthanide complex is modulated by the phosphorylation state of a serine residue in the sequence. While the phosphorylated state is weakly emissive, even in the presence of an external antenna, removal of the phosphate allows coordination of the sensitizer to the metal, yielding a highly emissive supramolecular complex. |
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