Effect of water on physical transitions of human serum albumin |
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Authors: | V F Ur’yash N Yu Kokurina |
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Institution: | 1.Research Institute of Chemistry,Nizhni Novgorod State University,Nizhni Novgorod,Russia |
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Abstract: | Differential thermal analysis is performed for native human serum albumin, denatured human serum albumin, and their mixtures
with water in the range 80–550 K. The temperatures of phase transitions of the protein are determined, and the effect of water
on these transitions is ascertained. The limit of water solubility in the native protein is estimated from the calorimetry
data on the enthalpy of melting of the excess-water phase. The phase diagram of the albumin-water system is plotted and analyzed
in wide temperature and concentration ranges. |
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