Microwave-Assisted Solid-Phase Synthesis of Cephalosporin Derivatives with Antibacterial Activity |
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| Authors: | Mazaahir Kidwai Preeti Misra Kumar R. Bhushan Rajendra K. Saxena Meena Singh |
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| Affiliation: | (1) Department of Chemistry, University of Delhi, Delhi-110007, India, IN;(2) Department of Microbiology, University of Delhi, New Delhi-110021, India, IN |
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| Abstract: | Summary. The reaction of heterocyclic acids with 7-amino-cephalosporanic acid adsorbed on basic alumina under microwave irradiation afforded the N-acylated cephalosporin analogues in satisfactory yield. All compounds were tested for their antibacterial activity; some of them showed significant antibacterial properties. Cefotaxime and cephalothin were used as reference drugs. Received February 23, 2000. Accepted March 28, 2000 |
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| Keywords: | . 7-Aminocephalosporanic acid Solid support Microwave irradiation Antibacterial activity. |
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