| 聚[1,3-双(对羧基苯氧基)丙烷-癸二酸](20:80)-替莫唑胺长效缓释微球的制备及药物缓释性能的研究 |
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| 引用本文： | 汤宇,尹维斌,李朝兴,王镇.聚[1,3-双(对羧基苯氧基)丙烷-癸二酸](20:80)-替莫唑胺长效缓释微球的制备及药物缓释性能的研究[J].离子交换与吸附,2006,22(6):565-570. |
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| 作者姓名： | 汤宇 尹维斌 李朝兴 王镇 |
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| 作者单位： | 南开大学化学学院,高分子化学研究所,天津,300071 |
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| 摘 要： | 合成了聚1,3-双(对羧基苯氧基)丙烷-癸二酸](20:80)(CPP-SA),并利用喷雾干燥法制备了替莫唑胺Temozolomide(TMZ)-(CPP-SA)缓释微球。通过对TMZ的不同包合方法的研究,确定了喷雾干燥法作为制备此类微球的最佳方法,获得了良好的药物缓释曲线。结果表明,微球对药物释放曲线平稳,释放时间长,能超过800h。为抗肿瘤药物TMZ的体内植入提供了有意义的理论依据。
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| 关 键 词： | 聚[1 3-双(对羧基苯氧基)丙烷-癸二酸] 替莫唑胺 喷雾干燥 药物缓释 生物降解 |
| 文章编号： | 1001-5493(2006)06-0565-06 |
| 收稿时间： | 2006-02-12 |
| 修稿时间： | 2006年2月12日 |
THE PREPARATION OF LONGER RELEASE MICROSPHERES OF CPP-SA-TMZ AND STUDIES ON THE RELEASE PROPERTIES |
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| TANG Yu,YANG Hailong,LI Chaoxing,WANG Zhen.THE PREPARATION OF LONGER RELEASE MICROSPHERES OF CPP-SA-TMZ AND STUDIES ON THE RELEASE PROPERTIES[J].Ion Exchange and Adsorption,2006,22(6):565-570. |
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| Authors: | TANG Yu YANG Hailong LI Chaoxing WANG Zhen |
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| Institution: | The Institute of Polymer Chemistry, Nankai University, Tianjin 300071, China |
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| Abstract: | The microsphere of the poly-1,3-bis(p-caboxyphenyloxy)-sebacic acid] has been prepared by the fine spray and drying method.The good release curves of the Temozolomide(TMZ)medicine have been drawled by through study of various clathrated methods.The results show that the release of TMZ is stable,and the release time is longer,it has been over 800 hrs.The results not only provide scientific basis for the planting in bodies of the anti-cancer medicine TMZ,but also extend application perspective for the new biodegradable polymer. |
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| Keywords: | Poly-[1 3-bis(p-caboxyphenyloxy)-sebacic acid] Temozolomide Spray and drying method Release Biodegradable |
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