|
|||||
|
|
Plasmonic nanoprobes for intracellular sensing and imaging |
|
| Authors: | Hsiangkuo Yuan Janna K. Register Hsin-Neng Wang Andrew M. Fales Yang Liu Tuan Vo-Dinh |
| Affiliation: | 1. Fitzpatrick Institute of Photonics, Department of Biomedical Engineering, Duke University, Durham, NC, 27708, USA 2. Fitzpatrick Institute of Photonics, Department of Chemistry, Duke University, Durham, NC, 27708, USA |
| Abstract: | Recent advances in integrating nanotechnology and optical microscopy offer great potential in intracellular applications with improved molecular information and higher resolution. Continuous efforts in designing nanoparticles with strong and tunable plasmon resonance have led to new developments in biosensing and bioimaging, using surface-enhanced Raman scattering and two-photon photoluminescence. We provide an overview of the nanoprobe design updates, such as controlling the nanoparticle shape for optimal plasmon peak position; optical sensing and imaging strategies for intracellular nanoparticle detection; and addressing practical challenges in cellular applications of nanoprobes, including the use of targeting agents and control of nanoparticle aggregation. Plasmonic nanoprobe characterization (TEM, simulation) and applications in pH sensing, SERS mapping, and TPL imaging |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |