Amidoalkylation of hydrophosphoryl compounds |
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Authors: | M E Dmitriev E A Rossinets V V Ragulin |
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Institution: | 1.Institute of Physiologically Active Substances,Russian Academy of Sciences,Chernogolovka, Moscow oblast,Russia |
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Abstract: | A new mild procedure of the amidoalkylation of hydrophosphoryl compounds in a mixture of acetic anhydride and acetyl chloride
was developed as a convenient method of constructing the α-aminophosphoryl fragment of the pseudo-α,α′-dipeptide molecule.
The reaction intermediates N,N′-benzylidene- and N,N′-alkylidenebiscarbamates were detected, isolated, and identified. The report presents the results of studying the direct
interaction of hydrophosphoryl compounds previously synthesized with biscarbamates in acetic anhydride and other solvents,
the influence of the structure of phosphorus component and biscarbamate, and the effect of acid catalysis on the course of
this two-component reaction. A new version of the mechanism of the three-component reaction of amidoalkylation of hydrophosphoryl
compounds is suggested: it is regarded as a multistage process involving the stage of biscarbamate formation followed by the
stage of Arbuzov-type reaction with the intermediate formation of acyliminium cation and P-OAc derivative with trivalent phosphorus. |
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