Synthesis of New Chiral Building Blocks for Novel Peptide Nucleic Acids |
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引用本文: | 吴杰,许笑宇,刘克良. Synthesis of New Chiral Building Blocks for Novel Peptide Nucleic Acids[J]. 中国化学, 2003, 0(5) |
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作者姓名: | 吴杰 许笑宇 刘克良 |
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作者单位: | Beijing Institute of Pharmacology and Toxicology,Beijing 100850,China,Beijing Institute of Pharmacology and Toxicology,Beijing 100850,China,Beijing Institute of Pharmacology and Toxicology,Beijing 100850,China |
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基金项目: | ProjectsupportedbytheNationalNaturalScienceFoundationofChina (No .2 0 172 0 70 )andtheMajorStateBasicResearchDevelopmentPro gram (No .G19985 110 3 ) |
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摘 要: | IntroductionAbouttenyearsago ,PNA ,astructuralmimicofDNAinwhichthesugar phosphatebackboneisreplacedbyN (2 aminoethyl)glycine (aeg)linkageemergedasapotentialanti sensetherapeuticagent.1PNAhassomeadvantages:(1)itisstabletocellularnucleasesandproteases,(2 )ithybridizeswithcomplementaryDNAorRNA (cDNA/RNA)sequenceswithhighaffinity ,(3)ithaslownon specificinteractionwithcellularcontentsand (4 )itiseasilysynthesizedbyadoptionofsolidphasepeptidesynthesischemistry .However,thema jorlimitationo…
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Synthesis of New Chiral Building Blocks for Novel Peptide Nucleic Acids |
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Abstract: | N Boc protected amino acids of analogues of peptide nucleic acid (PNA), which are a class of conformationally constrained building blocks based on 4 aminoproline backbone with chirality at 2 C and 4 C, have been synthesized. Those monomers can be used for the construction of novel peptide nucleic acid analogues. |
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Keywords: | oligonucleotide peptide nucleic acids pyrrolidine synthesis |
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