| Synthesis of New Chiral Building Blocks for Novel Peptide Nucleic Acids |
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| 作者姓名： | 吴杰 许笑宇 刘克良 |
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| 作者单位： | Beijing Institute of Pharmacology and Toxicology，Beijing 100850，China，Beijing Institute of Pharmacology and Toxicology，Beijing 100850，China，Beijing Institute of Pharmacology and Toxicology，Beijing 100850，China |
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| 基金项目： | ProjectsupportedbytheNationalNaturalScienceFoundationofChina (No .2 0 172 0 70 )andtheMajorStateBasicResearchDevelopmentPro
gram (No .G19985 110 3 ) |
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| 摘 要： | IntroductionAbouttenyearsago ,PNA ,astructuralmimicofDNAinwhichthesugar phosphatebackboneisreplacedbyN (2 aminoethyl)glycine (aeg)linkageemergedasapotentialanti sensetherapeuticagent.1PNAhassomeadvantages:(1)itisstabletocellularnucleasesandproteases,(2 )ithybridizeswithcomplementaryDNAorRNA (cDNA/RNA)sequenceswithhighaffinity ,(3)ithaslownon specificinteractionwithcellularcontentsand (4 )itiseasilysynthesizedbyadoptionofsolidphasepeptidesynthesischemistry .However,thema jorlimitationo…
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Synthesis of New Chiral Building Blocks for Novel Peptide Nucleic Acids |
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| Abstract: | N Boc protected amino acids of analogues of peptide nucleic acid (PNA), which are a class of conformationally constrained building blocks based on 4 aminoproline backbone with chirality at 2 C and 4 C, have been synthesized. Those monomers can be used for the construction of novel peptide nucleic acid analogues. |
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| Keywords: | oligonucleotide peptide nucleic acids pyrrolidine synthesis |
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