Synthesis of the putative minimal FGF binding motif heparan sulfate trisaccharides by an orthogonal protecting group strategy |
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| Authors: | János Tatai |
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| Institution: | Department of Carbohydrate Chemistry, Chemical Research Center, Hungarian Academy of Sciences, Pusztaszeri út 59-67, H-1025 Budapest, Hungary |
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| Abstract: | The synthesis of two trisaccharides, the putative minimal heparan sulfate sequences responsible for binding to acidic and basic fibroblast growth factors, respectively, is described from a common protected intermediate using an orthogonal protecting group strategy. |
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| Keywords: | Oligosaccharide synthesis Heparin Heparan sulfate Fibroblast growth factors Binding epitope Orthogonal protection |
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