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A new, one-pot, multi-component synthesis of imines of 3-amino-2-arylimidazo[1,2-a]pyridines, 3-amino-2-arylimidazo[1,2-a]pyrazines, and 3-amino-2-arylimidazo[1,2-a]pyrimidines |
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| Authors: | Mehdi Adib Esmail Sheibani Long-Guan Zhu |
| Affiliation: | a School of Chemistry, University College of Science, University of Tehran, PO Box 14155-6455, Tehran, Iran b Department of Chemistry, Tarbiat Modarres University, PO Box 14115-175, Tehran, Iran c Chemistry Department, Zhejiang University, Hangzhou 310027, PR China |
| Abstract: | An efficient, one-pot, multi-component synthesis of 3-amino-2-arylimidazo[1,2-a]pyridines, 3-amino-2-arylimidazo[1,2-a]pyrazines, and 3-amino-2-arylimidazo[1,2-a]pyrimidines is described. Heating a mixture of a 2-aminopyridine, 2-aminopyrazine or 2-aminopyrimidine, a benzaldehyde, and imidazoline-2,4,5-trione under solvent-free conditions afforded imine derivatives of the title compounds in excellent yields. Single-crystal X-ray analysis conclusively confirms the structure of these bridgehead bicyclic 5-6 heterocycles. |
| Keywords: | 2-Aminopyridines 2-Aminopyrazine 2-Aminopyrimidine Benzaldehydes Imidazoline-2,4,5-trione 3-Amino-2-arylimidazo[1,2-a]pyridines 3-Amino-2-arylimidazo[1,2-a]pyrazines 3-Amino-2-arylimidazo[1,2-a]pyrimidines Multi-component reactions |
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