A general and efficient method for the synthesis of benzo-(iso)quinoline derivatives |
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| Authors: | Victor Mamane,Fré dé ric Louë rat,Julien Iehl,Mohamed Abboud,Yves Fort |
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| Affiliation: | Equipe Synthèse Organométallique et Réactivité (SOR), Laboratoire SRSMC, UMR CNRS-UHP 7565, Nancy Université, BP 239, Bd des Aiguillettes, 54506 Vandoeuvre-les-Nancy, France |
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| Abstract: | A new, short and efficient synthesis of substituted benzo-(iso)quinoline derivatives is reported. The methodology is based on a Suzuki or Negishi cross-coupling followed by a cyclization reaction induced by t-BuOK in DMF to form the central ring. This approach allowed the synthesis of all four benzo-(iso)quinoline isomers and the substitution of each ring of the benzo-(iso)quinoline core. |
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