Greatly attenuated experimental autoimmune encephalomyelitis in aquaporin-4 knockout mice |
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Authors: | Lihua Li Hua Zhang AS Verkman |
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Affiliation: | (1) Departments of Medicine and Physiology, University of California, San Francisco, California, USA |
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Abstract: | Background The involvement of astrocyte water channel aquaporin-4 (AQP4) in autoimmune diseases of the central nervous system has been suggested following the identification of AQP4 autoantibodies in neuromyelitis optica, an inflammatory demyelinating disease. |
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