A new anticancer dihydroflavanoid from the root of Spiranthes australis (R. Brown) Lindl |
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Authors: | Peng Jinyong Xu Qiwei Xu Youwei Qi Yan Han Xu Xu Lina |
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Institution: | School of Pharmacy, Dalian Medical University, Dalian 116027, China. jinyongpeng2005@163.com |
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Abstract: | A new dihydroflavanoid was obtained from the root of Spiranthes australis (R. Brown) Lindl, a traditional Chinese medicinal herb. The structure was elucidated as (2S)-5,2',6'-trihydroxy-6-lavandulyl-4'-(gamma,gamma-dimethylallyl)-2',2'-dimethylpyrano-5',6' : 7,8]-flavanone by spectroscopic methods including UV, IR, HR-EI-MS, ESI-MS, 1D NMR and 2D NMR techniques, and subsequently, the anticancer activities of the compound to inhibit human cancer cells' growth including A549, BEL-7402, SGC-7901, MCF-7, HT-29, K562, and A498 cell lines by MTT method was evaluated in vitro. |
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