Synthesis and characterisation of macrocyclic diamino chiral crown ethers |
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Authors: | Correa Waldo H Scott Janet L |
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Institution: | Centre for Green Chemistry, Monash University, P.O. Box 23, Victoria, 3800, Australia. waldo.correa@sci.monash.edu.au |
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Abstract: | A benign and efficient synthesis of chiral macrocyclic 'aza-crown' ethers of varying ring size is reported. The synthesis involves a Schiff base condensation of ether linked dialdehydes of varying chain length and (1R,2R)-(-)-1,2-diaminocyclohexane under mild conditions to yield the macrocycles, which are subsequently reduced to yield the diamino analogues. |
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