Development of a thermal neutron-sensitive liposome for a novel drug delivery system aiming for radio-chemo-concurrent cancer therapy |
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Authors: | Ken Akamatsu |
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Affiliation: | aRadiation Effect Analysis Group, Nuclear Science and Engineering Directorate, Japan Atomic Energy Agency, 2-4 Shirakatashirane, Tokai, Naka, Ibaraki 319-1195, Japan |
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Abstract: | A thermal neutron-sensitive liposome has been developed focusing on irradiation site-specific-controlled release of a medicine. We recommended a 10B-borocaptate dimer as a detonator of liposome in expectation of effects of low-energy heavy ions produced by 10B(n, α)7Li reaction. As a result, an X-ray-sensitive liposome incorporating the detonator was vulnerable enough to release an anticancer agent, carboplatin, at a dose/dose–rate near clinical use. These results reveal, moreover, that the liposomes are also applicable to a heavy-ion beam. |
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Keywords: | Drug delivery system Thermal neutron Liposome Ionizing radiation Cancer therapy |
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