| 含硅混合烃基卤化锡的合成与结构表征及生物活性 |
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| 引用本文： | 林森,付志飞,刘环宇,邓瑞红,孙小强,汪信.含硅混合烃基卤化锡的合成与结构表征及生物活性[J].南昌大学学报(理科版),2006,30(1):32-35. |
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| 作者姓名： | 林森 付志飞 刘环宇 邓瑞红 孙小强 汪信 |
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| 作者单位： | 1. 南昌大学,化学系,江西,南昌,330047;南京理工大学,化工学院,江苏,南京,210094
2. 南昌大学,化学系,江西,南昌,330047 |
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| 摘 要： | 合成了7个含硅烃基卤化锡。通过元素分析、IR、^1H NMR和^13C NMR测定了这些化合物的结构。生物活性试验的初步结果显示，4个含硅二烃基二卤化锡对宫颈癌（Hela）和肺癌（SPC-A-1）的癌细胞具有较好的体外抗癌活性，3个三烃基卤化锡具有良好的杀菌和杀螨活性。
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| 关 键 词： | 含硅烃基卤化锡 合成 结构表征 生物活性 |
| 文章编号： | 1006-0464（2006）01-0032-04 |
| 收稿时间： | 2005-03-04 |
| 修稿时间： | 2005年3月4日 |
The Synthesis,Characterization and Biological Activity of Organotin Halides Containing Silicon |
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| LIN Sen,FU Zhi-Fei,LIU Huan-Yu,DENG Rui-hong,SUN Xiao-qiang,WANG Xin.The Synthesis,Characterization and Biological Activity of Organotin Halides Containing Silicon[J].Journal of Nanchang University(Natural Science),2006,30(1):32-35. |
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| Authors: | LIN Sen FU Zhi-Fei LIU Huan-Yu DENG Rui-hong SUN Xiao-qiang WANG Xin |
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| Institution: | 1. Department of Chemistry, Nanchang University, Nanchang, 330047, China ; 2. School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing,210094, China |
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| Abstract: | Seven organotin halides containing silicon were synthesized and characterized by elemental analysis,IR,^1H NMR and ^13C NMR. The preliminary bioassay tests showed that four diorganotin halides have a good antitumour activity in vitro against Hela and SPC - A - 1 tumour cells ,three triorganotin halides have antigermina and miticical activity. |
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| Keywords: | organotin halide containing silicon synthesis structural analysis biological activity |
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