One-pot, two-step conversion of aldehydes to phosphonyl- and sulfonylpyrazoles using bestmann-ohira reagent |
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| Authors: | Rahul Kumar Deepti Verma Shaikh M Mobin Irishi N N Namboothiri |
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| Affiliation: | Department of Chemistry and National Single-Crystal X-ray Diffraction Facility, Indian Institute of Technology , Bombay, Mumbai 400 076, India. |
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| Abstract: | A one-pot, two-step, three-component method for the conversion of commercially available aldehydes to phosphonylpyrazoles has been developed, demonstrating, for the first time, the dual reactivity of the Bestmann-Ohira reagent (BOR) in a single-pot transformation. This method, extended to the synthesis of sulfonylpyrazoles by employing BOR in the first step and a diazomethyl sulfone in the second step, is complementary, with regard to regioselectivity, to the previous methods for the synthesis of such functionalized pyrazoles. |
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