Simple one-pot process for the bioresolution of tertiary amino ester protic ionic liquids using subtilisin |
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| Authors: | Maude Brossat Thomas S Moody Stephen JC Taylor Jonathan W Wiffen |
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| Institution: | aBiocatalysis Group, Almac Sciences, David Keir Building, Stanmillis Road, Belfast BT9 5AG, Northern Ireland |
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| Abstract: | An efficient hydrolase-catalyzed bioresolution of tertiary amino ester protic ionic liquids has been demonstrated. Protic ionic liquids have been prepared in one step from the corresponding tertiary amino alcohols by treatment with butyric anhydride. After bioresolution, unreacted esters can be easily separated from the corresponding alcohols by extraction with hexane. Bioresolution of quinuclidin-3-yl butyrate has been performed with excellent selectivity. |
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