MRI study of Fickian, case II and anomalous diffusion of solvents into hydroxypropylmethylcellulose |
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Authors: | J Tritt-Goc J Kowalczuk N Piślewski |
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Institution: | 1. Institute of Molecular Physics, Polish Academy of Sciences, M. Smoluchowskiego 17, 60-179, Poznań, Poland
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Abstract: | Magnetic resonance imaging was used to investigate the diffusion and swelling processes of a hydroxypropylmethylcellulose
(HPMC) matrix. Polymer in the form of a cylinder was hydrated in a water solvent with pH 2, 7, and 12 at 37 °C and monitored
at equal intervals on a Bruker Avance 300 MHz spectrometer. The spatially resolved spin-spin relaxation times and spin densities
together with the change in the dimension of the glass core of the polymer were determined for the HPMC tablets as a function
of hydration times. FromT
2 parameters, the solvent molecule mobility within the gel layer of the HPMC was estimated. All studied parameters allow the
determination of the diffusion of the solvent into the HPMC matrix as Fickian diffusion for alkaline solvents, case II for
acidic solvent, and anomalous diffusion for neutral solvent. |
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Keywords: | |
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