Stereospezifität der neuroleptischen Wirkung und Chiralität von (+)-3-{2-[4-(8-Fluor-2-methyl-10,11-dihydrodibenzo[b,f]thiepin-10-yl)-1-piperazinyl]-äthyl}-2-oxazolidinon (16). 4. Mitteilung über tricyclische Antidepressiva und Neuroleptica |
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Authors: | Werner Aschwanden Emilio Kyburz Peter Schnholzer |
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Institution: | Werner Aschwanden,Emilio Kyburz,Peter Schönholzer |
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Abstract: | Stereospecifity of the neuroleptic activity and chirality of (+)-3-{2-4-(8-fluoro-2-methyl-10, 11-dihydrodibenzob,f]thiepin-10-yl)-1-piperazinyl]ethyl}-2-oxazolidinone (16). The synthesis and stereospecific neuroleptic action in animals of the (+)-enantiomer of 3-{2-4-(8-fluoro-2-methyl-10,11-dihydrodibenzo b,f]thiepin-10-yl)-1-piperazinyl]ethyl}-2-oxazolidinone ( 16 ) are briefly described. The (10S)-configuration of this compound was determined by X-ray diffraction. |
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