| 单分散壳聚糖微囊的制备与表征 |
| |
| 引用本文： | 杨建平,魏刚,巨晓洁,褚良银.单分散壳聚糖微囊的制备与表征[J].化学研究与应用,2009,21(5). |
| |
| 作者姓名： | 杨建平 魏刚 巨晓洁 褚良银 |
| |
| 作者单位： | 四川大学化工学院,四川,成都,610065 |
| |
| 基金项目： | 国家自然科学基金，教育部高等学校博士学科点专项科研基金，四川省青年科技基金后续资助计划项目 |
| |
| 摘 要： | 对水溶性壳聚糖和对苯二甲醛在水/油界面发生的交联反应进行了研究,考察了水相溶液的pH值和油相中对苯二甲醛的浓度对该界面交联反应的影响.采用微流控技术制备得到了单分散的壳聚糖微囊:首先通过毛细管同轴聚焦流微流控装置制备得到单分散的O/W/O乳液.乳液制备中,以Pluronic F-127作为水相乳化剂,羟乙基纤维素作为水相增稠剂,水溶性壳聚糖溶于中间水相;交联剂对苯二甲醛溶于内部油相;含乳化剂PGPR 90的大豆油作为外部油相.乳液制备完成后,以乳液为模板,对苯二甲醛通过油/水界面扩散进入水层,与壳聚糖的氨基发生交联反应,生成壳聚糖聚合物凝胶网络,从而构成微囊的囊壁.通过光学显微镜分析和扫描电镜观察发现:微囊具备良好的单分散性和球形度以及尺寸均一的内部空腔,微囊的囊壁致密无孔.所得单分散微囊在药物传递等领域具备潜在的应用价值.
|
| 关 键 词： | 壳聚糖 对苯二甲醛 单分散微囊 微流控技术 |
Preparation and characterization of monodisperse chitosan microcapsules |
| |
| YANG Jian-ping,WEI Gang,JU Xiao-jie,CHU Liang-yin.Preparation and characterization of monodisperse chitosan microcapsules[J].Chemical Research and Application,2009,21(5). |
| |
| Authors: | YANG Jian-ping WEI Gang JU Xiao-jie CHU Liang-yin |
| |
| Institution: | School of Chemical Engineering;Sichuan University;Chengdu 610065;China |
| |
| Abstract: | The interfacial cross-linking reaction of water-soluble chitosan with oil-soluble terephthalaldehyde was firstly investigated.Effects of the pH of chitosan aqueous solution and the concentration of terephthalaldehyde in oil phase on the cross-linking reaction were examined.Monodisperse oil-in-water-in-oil emulsions were successfully fabricated within a microcapillary coaxial flow-focusing device.Water-soluble chitosan was dissolved into the aqueous phase which containing Pluronic F-127 as emulsifier and hyd... |
| |
| Keywords: | chitosan terephthalaldehyde monodisperse microcapsules microfluidic technology |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
