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Computational Modelling of the Behaviour of Potentiometric Membrane Biosensors |
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| Authors: | R Baronas F Ivanauskas J Kulys |
| Institution: | (1) Faculty of Mathematics and Informatics, Vilnius University, Naugarduko 24, LT-03225 Vilnius, Lithuania;(2) Institute of Mathematics and Informatics, Akademijos 4, LT-08663 Vilnius, Lithuania;(3) Department of Chemistry and Bioengineering, Vilnius Gediminas Technical University, Sauletekio al. 11, LT-10223 Vilnius, Lithuania |
| Abstract: | This paper presents a mathematical model of a potentiometric biosensor based on a potentiometric electrode covered with an enzyme membrane. The model is based on the reaction–diffusion equations containing a non-linear term related to theMichaelis–Menten kinetics of the enzymatic reaction. Using computer simulation the influence of the thickness of the enzyme membrane on the biosensor response was investigated. The digital simulation was performed using the finite difference technique. Results of the numerical simulation were compared with known analytical solutions. |
| Keywords: | reaction– diffusion modelling biosensor potentiometry |
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