| 紫外分光光度法同时测定复方甲硝唑片中甲硝唑和维生素B6的含量 |
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| 引用本文： | 唐万军,陈栋华,王利华,袁誉洪.紫外分光光度法同时测定复方甲硝唑片中甲硝唑和维生素B6的含量[J].中南民族大学学报(自然科学版),2005,24(3):13-16. |
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| 作者姓名： | 唐万军 陈栋华 王利华 袁誉洪 |
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| 作者单位： | College of Chemistry and Material Science, South-Central University for Nationalities. Wuhan 430074 |
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| 基金项目： | 中南民族大学校科研和教改项目 |
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| 摘 要： | 建立了一种简单、快速、能同时测定复方甲硝唑片中甲硝唑与维生素B6的方法.采用0.100 mol/L NaOH和2.0%的四硼酸钠溶液为介质,测定波长为288和320 nm.维生素B6的存在不干扰甲硝唑的直接测定.赋形剂对该测定方法不干扰.甲硝唑的回收率为96.6% ～ 102.0%,RSD为1.6% ～ 3.8%;维生素B6的回收率为95.2% ～ 106.3%,RSD为5.4%～8.1%.该方法简单、成本低、易于操作.
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| 关 键 词： | 紫外分光光度法 甲硝唑 维生素B6 复方甲硝唑片 药物分析 |
| 文章编号： | 1672-4321（2005）03-0013-04 |
| 收稿时间： | 2005-06-28 |
| 修稿时间： | 2005年6月28日 |
Simultaneous Assay of Metronidazole and Vitamin B6 for Compound Metronidazole Tablets by Using UV Spectrophotometry |
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| Tang Wanjun,Chen Donghua,Wang Lihua,Yuan Yuhong.Simultaneous Assay of Metronidazole and Vitamin B6 for Compound Metronidazole Tablets by Using UV Spectrophotometry[J].Journal of South-Central Univ for,2005,24(3):13-16. |
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| Authors: | Tang Wanjun Chen Donghua Wang Lihua Yuan Yuhong |
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| Institution: | South-Central University for Nationalities |
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| Abstract: | A simple and fast procedure is established for simultaneous determination of metronidazole and vitamin B6 in compound metronidazole tablets. Using 0.100 mol/L of NaOH and 2.0% borax as medium, and two detection wavelengths are 288 and 320 nm respectively. The presence of vitamin B6 does not interfere in the direct quantitative determination of metronidazole. Common excipients used do not interfere in the proposed method. The recoveries were 96.6% ~ 102.0% for metronidazole and 95.2% ~ 106.3% for vitamin B6, and RSDs were 1.6% ~ 3.8% for metronidazole and 5.4% ~ 8.1% for vitamin B6. The described method is simple, low cost, and easy to operate. |
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| Keywords: | UV method metronidazole vitamin B6 compound metronidazole tablets pharmaceutical assay |
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