Unprecedented palladium-catalyzed cross-coupling reaction of alpha-bromo sulfoxides with boronic acids |
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Authors: | Rodríguez Nuria Cuenca Ana Ramírez de Arellano Carmen Medio-Simón Mercedes Asensio Gregorio |
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Affiliation: | Departamento de Química Orgánica, Universidad de Valencia, Avda Vicent Andres Estelles s/n 46100 Burjassot-Spain. |
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Abstract: | [reaction: see text] A new Suzuki-type palladium-catalyzed reaction of boronic acids with alpha-bromo sulfoxides has been developed using a protocol similar to the well-documented reaction of boronic acids with aryl halides. Both cross-coupling and homocoupling processes were observed. The best yields in cross-coupling products were obtained when the presence of oxygen was carefully excluded using degassed solvents. The oxidative addition palladium complex intermediate could be isolated and characterized by X-ray single-crystal diffraction. |
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