Abstract: | Recent synthetic works of carbapenems, focused on their efficiency and applicability to synthesize a variety of substituted carbapenem derivatives for the effective screening research of the new generation carbapenem antibiotics, are reviewed.Part of this review was published in Japanese [Yuki Gosei Kagaku Kyokaishi, 54, 761 (1996); Chem. Abstr., 125, 221386 (1996)].Sumitomo Pharmaceuticals Research Center 1–98, Kasugadenaka 3-chome, Konohana-ku, Osaka 554, Japan. Published in Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1475–1493, November, 1998. |