| 新型金属胶束模拟酶对羧酸酯与磷酸酯的催化水解 |
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| 引用本文： | 戴秋云,邓云度,史真.新型金属胶束模拟酶对羧酸酯与磷酸酯的催化水解[J].化学学报,1998,56(10):1009-1014. |
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| 作者姓名： | 戴秋云 邓云度 史真 |
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| 作者单位： | 北京药物化学研究所.北京(102205);西北大学化学系.西安(710069) |
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| 基金项目： | 国家自然科学基金资助项目(29275224) |
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| 摘 要： | 报道了三种新的含醇羟基、胺基或咪唑基长链配体与铜锌离子构成的金属胶束对几种羧酸酯与磷酸酯底物催化水解动力学。结果表明,设计的金属胶束N-十四烷基-2-(N-2'-羟乙基氨基甲基)咪唑锌铜(2a,2b)在共胶束CTAB(溴化十六烷基三甲铵)存在下,对强配位羧酸酯对硝基苯酚-2-吡啶甲酸酯具有很强的催化水解能力,对磷酸酯对硫磷具有很高的反应性,2a,2b的醇羟基参与了对弱配位底物羧酸酯及磷酸酯的进攻,对不同电荷性质的羧酸酯底物具有较强的静电选择性。
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| 关 键 词： | 模拟酶 金属胶束 咪唑P 锌化合物 铜化合物 酶水解 酶促 反应动力学 磷酸酯 羧酸酯 |
| 修稿时间： | 1997年6月10日 |
Hydrolysis of carboxylate and phosphate esters catalyzed by new metallomicellar models of hydrolytic enzymes |
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| DAI Qiu-yun,DENG Yun-Du,SHI Zhen.Hydrolysis of carboxylate and phosphate esters catalyzed by new metallomicellar models of hydrolytic enzymes[J].Acta Chimica Sinica,1998,56(10):1009-1014. |
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| Authors: | DAI Qiu-yun DENG Yun-Du SHI Zhen |
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| Institution: | Beijing Pharmaceut Chem Inst, POB 1044 403.Beijing(102205);Northwest Univ, Dept Chem.Xian(710069) |
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| Abstract: | This article reportd the hydrolytic kinetics of carboxylate and phosphate esters catalyzed by the new metallomicelles formed from Cu2+ or Zn2+ and long chain ligands with alcohol hydroxyl, amino or imidazolyl groups. The results showed that the matallomicelle formed from Zn2+ or Cu2+ and N -tetradecyl -2-(N-2'- hydroxyethyl aminomethyl ) - imidazol in the presence of cetyltrimethylammonium bromide could catalyze the hydrolysis of p - nitrophenyl picolinate and react with parathion rapidly, its alcohol hydroxyl took part in the attack on p - nitrophenol acetate and p -nitrophenol diphenol phosphate, In addition, this metallomicelle showed good electrostatic selectivity to anionic carboxylic esters. |
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| Keywords: | metallomicelle artificial enzyme hydrolysis carboxylic ester phosphate ester |
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