海带多糖对草酸钙结晶过程中晶相的影响

采用X射线衍射(XRD)、红外光谱(FTIR)、扫描电子显微镜(SEM)和原子吸收光谱(AAS)等方法研究了从海带中提取的硫酸多糖(SPS)对尿结石主要成分草酸钙结晶的影响。SPS可以稳定热力学亚稳定的二水草酸钙(COD)晶体。随着SPS浓度从0增加到0.60 mg·mL-1,COD晶体的质量百分比从0增加到100％；亚稳溶液中草酸钙的相对过饱和度从1.0增加到19.6。SPS可以稳定COD晶体在溶液中的存在并增加可溶性Ca2+离子的浓度，这有利于防止草酸钙结石形成。结果表明，SPS是一种潜在的防止草酸钙尿结石形成的药物。

Modulation of Polysaccharide Extracted from Laminaria on Phase Compositions of Urinary Crystal Calcium Oxalate

The influence of sulfate polysaccharide (SPS) isolated from marine algae Laminaria japonica aresch on the growth of urinary crystal calcium oxalate (CaO(xa)) was investigated by means of X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, and atomic absorption spectroscopy. SPS can stabilize thermodynamic metastable calcium oxalate dihydrate (COD) crystals. As the concentration of SPS increases from 0 to 0.60 mg x mL(-1), the mass percentage of COD crystals increases from 0 to 100%, and the relative supersaturation of calcium oxalate increases from 1.0 to 19.6. The ability of SPS to stabilize the existence of COD in aqueous solution and to increase the concentration of soluble calcium ions is favorable to the inhibition of CaO(xa) stone. Indicating that SPS is a potential green drug for prevention and cure of CaO(xa) urinary stones.